Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing

Elmlegy, Fatma Helmy; Khereba, Walied Mohamed; A. Elsayeh, Shaimaa M.; Mahran, Hesham Galal

doi:10.21608/ejptr.2025.374539.1024

Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing

Articles in Press

Document Type : Original Article

Authors

¹ Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Delta University for Science and Technology, Egypt.

² Department of Vascular and Endovascular Surgery, Faculty of Medicine, Al-Azhar University-New Damietta.

³ Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University.

10.21608/ejptr.2025.374539.1024

Abstract

Background: Venous ulcers are chronic open skin lesions resulting from venous hypertension. When conservative treatments fail, alternative approaches are necessary.
Purpose: This study aimed to evaluate the effectiveness of ultrasound-enhanced hyaluronic acid delivery (phonophoresis) for venous ulcer healing.
Materials and methods: Sixty-four venous ulcer patients participated in this randomized clinical trial. Participants were equally divided into two groups. Group A received a combination of topical hyaluronic acid gel and ultrasound therapy, while Group B received ultrasound followed by topical hyaluronic acid. Wound surface area was measured before and after four weeks of treatment.
Results: Group A showed a highly significant reduction in wound surface area (51.15%) compared to Group B (31.02%) (p = 0.001).
Conclusion: The study concluded that the combination of hyaluronic acid and ultrasound therapy via phonophoresis is more effective in venous ulcer healing than sequential treatment. This method provides a promising adjunct to traditional therapies for venous ulcer management.

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